Gene information
Official symbol ESR2
Official full name estrogen receptor 2
Gene type protein-coding gene
Chromosome14q23.2-q23.3
Alias symbolNR3A2; Erb; ER-beta
Gene familyNuclear hormone receptors
Resources
Entrez Gene 2100
HGNC HGNC:3468
Ensembl ENSG00000140009
Vega OTTHUMG00000141306
UCSC uc001xha.2
GO terms: 24 records
GO Description Category LogP Number of genes Detail
GO:0001558 regulation of cell growth GO Biological Processes -19.1123936 65 More
GO:0003707 nuclear steroid receptor activity GO Molecular Functions -2.55598907 3 More
GO:0004879 nuclear receptor activity GO Molecular Functions -3.42635044 5 More
GO:0005496 steroid binding GO Molecular Functions -8.57765300 12 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009755 hormone-mediated signaling pathway GO Biological Processes -4.05849698 16 More
GO:0010469 regulation of signaling receptor activity GO Biological Processes -13.5880476 20 More
GO:0030308 negative regulation of cell growth GO Biological Processes -7.25826751 14 More
GO:0030522 intracellular receptor signaling pathway GO Biological Processes -2.78567165 7 More
GO:0030547 signaling receptor inhibitor activity GO Molecular Functions -4.95041155 6 More
GO:0032355 response to estradiol GO Biological Processes -15.3711017 31 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0045926 negative regulation of growth GO Biological Processes -11.4342361 38 More
GO:0048019 receptor antagonist activity GO Molecular Functions -4.45292460 5 More
GO:0051090 regulation of DNA-binding transcription factor activity GO Biological Processes -25.8933515 78 More
GO:0051091 positive regulation of DNA-binding transcription factor activity GO Biological Processes -17.7436786 49 More
GO:0071383 cellular response to steroid hormone stimulus GO Biological Processes -3.35454241 16 More
GO:0071392 cellular response to estradiol stimulus GO Biological Processes -5.13834229 6 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071407 cellular response to organic cyclic compound GO Biological Processes -19.6857751 39 More
GO:0098531 ligand-activated transcription factor activity GO Molecular Functions -3.42635044 5 More
GO:2000272 negative regulation of signaling receptor activity GO Biological Processes -7.12747015 9 More
KEGG pathways: 7 records
KEGG Description Category LogP Number of genes Detail
hsa01522 Endocrine resistance KEGG Pathway -4.64858532 8 More
hsa04915 Estrogen signaling pathway KEGG Pathway -2.87451539 7 More
hsa04917 Prolactin signaling pathway KEGG Pathway -3.17844000 10 More
hsa04929 GnRH secretion KEGG Pathway -3.00923941 5 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05207 Chemical carcinogenesis - receptor activation KEGG Pathway -7.05448873 28 More
hsa05224 Breast cancer KEGG Pathway -6.01672252 21 More
Drug-Gene interaction
view
Related drugs: 61 records
Drug name Interaction type Source PMID View
abemaciclib PharmGKB view
acolbifene modulator ChemblInteractions view
afimoxifene modulator ChemblInteractions 15846122 view
alpelisib PharmGKB view
anastrozole PharmGKB view
arzoxifene TTD view
aus-131 agonist TdgClinicalTrialChemblInteractionsTTD 1588343115084758 view
bazedoxifene antagonist TdgClinicalTrial 15961563 view
bazedoxifene acetate modulator ChemblInteractions view
bithionol DTC view
chembl1222035 DTC 20659801105922351713928417016423 view
chembl2332580 DTC 23586645 view
chembl600336 DTC view
chf4227 modulator ChemblInteractions view
chlorotrianisene modulator ChemblInteractions view
cr 1447 agonist ChemblInteractions view
diethylstilbestrol diphosphate agonist ChemblInteractions view
docetaxel PharmGKB view
droloxifene modulator ChemblInteractions view
eribulin PharmGKB view
erteberel agonist ChemblInteractionsTTD 10592235 view
estradiol agonist DTCTdgClinicalTrialTEND 2065980123882126201141217464340165207332497181519561619 view
estramustine phosphate sodium modulator ChemblInteractions view
estrogen TdgClinicalTrialTTD view
estrogens, conjugated agonist ChemblInteractions view
estrogens, conjugated synthetic a agonist ChemblInteractions view
estrogens, esterified agonist ChemblInteractions view
everolimus PharmGKB view
exemestane PharmGKB view
fispemifene modulator TdgClinicalTrialChemblInteractions view
fulvestrant antagonist TALCDTCChemblInteractionsPharmGKB 19845386 view
gemcitabine PharmGKB 22838950 view
genistein agonist TTD 105922351713928417016423 view
goserelin PharmGKB view
idoxifene modulator ChemblInteractions view
ixabepilone PharmGKB view
lapatinib PharmGKB view
letrozole PharmGKB 26536870 view
ly2245461 modulator ChemblInteractions view
mf101 agonist TdgClinicalTrialChemblInteractionsTTD view
mk-6913 agonist TdgClinicalTrialChemblInteractions view
naringenin partial agonist TTD 9751507 view
neratinib PharmGKB view
olaparib PharmGKB view
ospemifene modulator TdgClinicalTrialChemblInteractions view
palbociclib PharmGKB view
pertuzumab PharmGKB view
prinaberel agonist ChemblInteractionsTTD 10592235 view
quinestrol agonist ChemblInteractions view
raloxifen TdgClinicalTrial view
raloxifene antagonistagonist DTCTdgClinicalTrialTENDPharmGKB 20659801104189791181003212097269117523521150084911861516 view
raloxifene hydrochloride modulator ChemblInteractions view
ribociclib PharmGKB view
sivifene TdgClinicalTrial view
sr16234 TdgClinicalTrial view
synthetic conjugated estrogens, b agonist ChemblInteractions view
tamoxifen agonistantagonist DTCTdgClinicalTrialTENDPharmGKB 1715875920827267206598011601041220114121632683017404078117523521682262417713466 view
toremifene TdgClinicalTrialPharmGKB view
toremifene citrate modulator ChemblInteractions view
trastuzumab PharmGKB view
trilostane allosteric modulator TTD 168069051710961512209583 view
Related studies: 8 records
Molecular factor Omics type Application Objective MI type Reference
NM_001437.3:c.[-789T>G;984G>A;*39G>A] genomics myocardial infarction[diagnosis] myocardial infarction Rexrode KM et al. Clin Chem. 2007
NM_001437.3:c.[-789T>G;984G>A;*39G>A] genomics myocardial infarction[diagnosis] myocardial infarction Domingues-Montanari S et al. Clin Chem. 2008
NM_001437.3:c.[-789T>G;984G>A;*39G>A] genomics myocardial infarction[diagnosis] myocardial infarction Domingues-Montanari S et al. Clin Chem. 2008
NM_001437.3:c.-789T>G genomics myocardial infarction[diagnosis] myocardial infarction Rexrode KM et al. Clin Chem. 2007
NM_001437.3:c.984G>A genomics myocardial infarction[diagnosis] myocardial infarction Rexrode KM et al. Clin Chem. 2007
NM_001437.3:c.-789T>G genomics myocardial infarction[diagnosis] myocardial infarction Domingues-Montanari S et al. Clin Chem. 2008
NM_001437.3:c.-789T>G genomics myocardial infarction[diagnosis] myocardial infarction Domingues-Montanari S et al. Clin Chem. 2008
NM_001437.3:c.*39G>A genomics myocardial infarction[diagnosis] myocardial infarction Ambroziak M et al. Gene. 2018
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